Bernhard Brüne

Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia

This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.

IL-38 limits alloreactivity through modulating myeloid and T cell activation

This study shows IL-38 reduces monocyte antigen presentation and promotes regulatory T-cell expansion, thereby limiting alloreactivity in GvHD models.

The Coronavirus Envelope Is Modulated by Host Inflammation and Enriched in Bioactive Lipids Required for Replication

This study characterizes the lipid composition of SARS-CoV-2 envelopes from cultured strains and patient isolates, showing inflammation-induced changes and identifying lipid targets for antiviral and antithrombotic strategies.

uORF-Tools - Workflow for the determination of translation-regulatory upstream open reading frames

The paper introduces a workflow for identifying functional upstream open reading frames (uORFs) using ribosome profiling data and provides a human uORF annotation file.

Hydrogen peroxide formation by Nox4 limits malignant transformation

The paper shows that Nox4 produces hydrogen peroxide, which prevents malignant transformation by regulating DNA repair and AKT activity.