High affinity enhancer-promoter interactions can bypass CTCF/cohesin-mediated insulation and contribute to phenotypic robustness
Shreeta Chakraborty, Nina Kopitchinski, Zhenyu Zuo, Ariel Eraso, Parirokh Awasthi, Raj Chari, Apratim Mitra, Ian C. Tobias, Sakthi D. Moorthy, Ryan Dale, Jennifer A. Mitchell, Timothy J. Petros, Pedro P. Rocha
The paper shows that high affinity enhancer-promoter interactions can bypass CTCF/cohesin insulation and maintain gene expression in some tissues but not others.
Nature Genetics · Jan 30, 2023Peer-reviewedDevelopmental Biology