Profiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia
Laura Corveleyn, Lien Provez, Osman Satilmis, Nina Refhagen, Mattias Landfors, Wouter Sleeckx, Béatrice Lintermans, A. De Maesschalck, Rishi Sury Kotecha, Barbara De Moerloose, Tim Lammens, Dieter L. D. Deforce, Sofie Degerman, Steven Goossens, Pieter Van Vlierberghe, Maarten Dhaenens
The paper uses mass spectrometry to profile histone post-translational modifications in T-ALL cell lines and identifies drug response signatures, but finds discrepancies between in vitro and in vivo models.
Scientific Reports · Mar 26, 2026Peer-reviewedCancer Biology