Pieter Van Vlierberghe

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia

This study identifies SOX11 as a driver of γδ-like T-cell acute lymphoblastic leukemia, showing its cooperation with LMO2 and MYCN to promote leukemogenesis.

Profiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia

The paper uses mass spectrometry to profile histone post-translational modifications in T-ALL cell lines and identifies drug response signatures, but finds discrepancies between in vitro and in vivo models.

Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells

The paper identifies NESPR, an adrenergic-specific lncRNA, as a regulator of neuroblastoma cell identity that prevents cell death by attenuating stress.

CCR1 inhibition sensitizes multiple myeloma cells toglucocorticoid therapy

This study shows that inhibiting CCR1 enhances the effectiveness of glucocorticoid therapy in multiple myeloma by reversing resistance mechanisms.

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T Cell Acute Lymphoblastic Leukemia

The paper identifies a novel mechanism where focal deletions of an intronic element in FTO lead to IRX3 activation in T-ALL through enhancer hijacking.