Kidney medulla macrophages maintain a free flow of urine by sensing force
Rukun He, Zhanghui Huang, Yanran Li, He Jl, Chipeng Guo, Qiang Wang, Ningting Chen, Yuancheng Weng, Xinge Wang, Xiaoli Liu, Xiao Z. Shen
This study identifies Piezo1 as a mechanoreceptor in kidney medulla macrophages that enables them to clear sedimentary particles and prevent kidney stones.
bioRxiv · Jul 8, 2026 · PreprintPhysiology