Kidney cortex macrophages strategically reabsorb phosphate from the urine to prevent the formation of mineral stones
Yuxi Wang, Yuancheng Weng, Xukai Ding, Ningting Chen, Qiang Wang, Zhaohui Lu, Ziqi Gao, Jianghua Chen, Feng Xu, Dandan Liang, Fei Han, Xiao Z. Shen
This study identifies kidney cortex macrophages as a novel source of phosphate reabsorption, preventing calcium phosphate stone formation by upregulating SLC34A1 in response to mineral crystals.
bioRxiv · Feb 18, 2025 · PreprintImmunology