Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males
Manish Gupta, Nishtha Nayyar, Jessica Shen, Shichun Lun, Sabal Chaulagain, Nikita Mangla, Oscar J Nino-Meza, Stefanie Krug, Geetha Srikrishna, Joseph P. Hoffmann, Eileen P. Scully, Sabra L. Klein, William R. Bishai
This study shows that gonadal sex, not chromosomal sex, influences TB susceptibility in mice, with males showing myeloid dysfunction and females showing enhanced immune responses.
bioRxiv · Jun 12, 2026 · PreprintImmunology