Sabra L. Klein

Sex differences in vaccine-induced neuraminidase cross-recognition impact H5N1 dissemination to the lower respiratory tract in mice

This study shows that sex differences in vaccine-induced neuraminidase (NA) antibody responses affect H5N1 virus dissemination in mice, with females showing better protection against lower respiratory tract infection.

Trimester-Dependent Vertical Transmission of H5N1 Influenza Virus Through Placental and Mammary Routes Impairs Offspring Development

This study shows H5N1 influenza virus can be transmitted vertically through placental and mammary routes in pregnant mice, causing developmental impairments in offspring.

Intrinsic T-cell programming and immune spatial organization govern sex-biased tuberculosis immunity

This study identifies intrinsic T-cell programming and pulmonary immune spatial organization as sex-dependent mechanisms governing tuberculosis immunity in mice.

Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males

This study shows that gonadal sex, not chromosomal sex, influences TB susceptibility in mice, with males showing myeloid dysfunction and females showing enhanced immune responses.

Mechanisms of sex differences in acute and long COVID sequelae in mice

This study identifies sex differences in long COVID sequelae in mice, showing that X-linked genes like Xist and Tlr7 contribute to persistent inflammation and cognitive impairments in females.

Airway Epithelial SARS-CoV-2 Infectious and Repair Responses: Relationships to Age, Sex, and Post-COVID Pulmonary Syndromes

This study examines SARS-CoV-2 infection and repair responses in human airway epithelial cells, finding prolonged and incomplete repair linked to long-COVID pulmonary symptoms.

Multi-System Dysregulation in Placental Malaria Contributes to Adverse Perinatal Outcomes in Mice

This study infects pregnant mice with Plasmodium berghei at different gestational stages to investigate how placental malaria affects perinatal outcomes and identifies immune and hormonal changes associated with adverse effects.

A Third COVID-19 Vaccine Dose in Kidney Transplant Recipients Induces Antibody Response to Vaccine and Omicron Variants but Shows Limited Ig Subclass Switching

This study evaluates antibody responses to a third dose of COVID-19 vaccine in kidney transplant recipients, finding reduced neutralizing antibodies and altered IgG subclass switching compared to healthy controls.

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.