Author

Jessica Shen

Johns Hopkins UniversityORCID 0000-0002-0210-9347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

William R. BishaiiD· 2 shared Benjamin N. KoleskeiD· 1 shared Courtney SchilliD· 1 shared Eileen P. ScullyiD· 1 shared Geetha Srikrishna· 1 shared Joseph P. HoffmanniD· 1 shared Manish Gupta· 1 shared Manish Kumar GuptaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

William R. BishaiORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 12, 2026

Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males

Manish Gupta, Nishtha Nayyar, Jessica Shen…·William R. Bishai

This study shows that gonadal sex, not chromosomal sex, influences TB susceptibility in mice, with males showing myeloid dysfunction and females showing enhanced immune responses.

1 citation

mouseexperimental assay

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MicrobiologyScience AdvancesPeer-reviewedJul 2, 2025

Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis Lineage 2

Benjamin N. Koleske, Courtney Schill, Rajagopalan Saranathan…·William R. Bishai

This study shows that loss of the PPE71-38 locus in Mycobacterium tuberculosis Lineage 2 increases stress response gene expression and triglyceride levels, contributing to hypervirulence.

8 citationstop 3%

proteomicsmetabolomics

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