Mapping the Modification Landscape of MHC-I Epitopes: A Framework for Immunogenic Peptidomimetic Antigen Design
Sarah E. Newkirk, Joey J. Kelly, Nita Hourn, Sobika Bhandari, Naomi Spencer, Marcos M. Pires
This paper evaluates peptidomimetic modifications of MHC-I epitopes to improve antigen design, finding position-dependent tolerance and non-additive effects on immunogenicity and pharmacokinetics.
bioRxiv · Mar 25, 2026 · PreprintImmunology