Author

Sobika Bhandari

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:E. coli· 1

Frequent Co-Authors

Marcos M. PiresiD· 5 shared Rachita DashiD· 3 shared Sarah E. NewkirkiD· 3 shared Andrew Spira· 2 shared George M. OngwaeiD· 2 shared Irene LeporiiD· 2 shared M. Sloan SiegristiD· 2 shared Mahendra D. ChordiaiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersPharmacology & Toxicology

Marcos M. PiresORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure-Dependent Effects of Lipid Conjugation on Cytosolic Accumulation in Escherichia coli and Mammalian Cells

Dylan J. Coffin, Sobika Bhandari, Liora E. Wittle, Karl L. Ocius, George M. Ongwae, Marcos M. Pires

This study shows lipid conjugates have different effects on cytosolic accumulation in E. coli and mammalian cells, highlighting context-dependent permeation strategies.

ACS Chemical Biology · Oct 7, 2026Peer-reviewedPharmacology & Toxicology

Molecular Determinants Governing the Antitubercular Activity of Griselimycin

Andrew Spira, Sydney Williams, Rachita Dash, Sarah E. Newkirk, Irene Lepori, Yuanhang Caroline Luo, Vaskar Chowhury, Sobika Bhandari, Zichen Liu, Jean A. Chmielewski, M. Sloan Siegrist, Marcos M. Pires

This study investigates the structure-activity relationship of griselimycin, identifying key amino acids and modifications that enhance its antitubercular activity.

bioRxiv · Sep 15, 2026 · PreprintPharmacology & Toxicology

Mapping the Modification Landscape of MHC-I Epitopes: A Framework for Immunogenic Peptidomimetic Antigen Design

Sarah E. Newkirk, Joey J. Kelly, Nita Hourn, Sobika Bhandari, Naomi Spencer, Marcos M. Pires

This paper evaluates peptidomimetic modifications of MHC-I epitopes to improve antigen design, finding position-dependent tolerance and non-additive effects on immunogenicity and pharmacokinetics.

bioRxiv · Mar 25, 2026 · PreprintImmunology

Split-luciferin Assay for Real-time Measurement of Cytosolic Molecular Accumulation in Live Mycobacteria

Rachita Dash, Andrew Spira, Irene Lepori, Sarah E. Newkirk, Sobika Bhandari, Noah Lucas, Mahendra D. Chordia, M. Sloan Siegrist, Marcos M. Pires

This paper introduces D-CLAP, a split-luciferin assay to measure real-time cytosolic accumulation of compounds in live mycobacteria, showing that modifying carboxylates increases accumulation and antimycobacterial activity.

bioRxiv · Nov 2, 2025 · PreprintMicrobiology

Profiling Cytosolic Drug Delivery in Mammalian Cells: A Generalizable Assay for Intracellular Accumulation

Sobika Bhandari, George M. Ongwae, Rachita Dash, Zichen Liu, Mahendra D. Chordia, Yuchen He, Marcos M. Pires

The paper introduces the CHAMP assay to measure cytosolic drug accumulation in mammalian cells, showing how molecular structure affects penetration.

bioRxiv · Jun 3, 2025 · PreprintBiochemistry