CD95/Fas Apoptosis Signal Initiation Depends on the Ligand Oligomerization State and Formation of Small Ligand-Receptor Complexes
Xiaoyue Shang, Nina Bartels, Nicolaas T M van der Voort, Andreas Neusch, Noah Salama, Gajen Thaventhiran, Ralf Kühnemuth, Suren Felekyan, Claus A. M. Seidel, Cornelia Monzel
This study investigates how CD95 ligand oligomerization and receptor-ligand stoichiometry influence apoptotic signaling, showing that trimeric ligands and bridging enhance receptor engagement and signaling potency.
bioRxiv · May 8, 2026 · PreprintBiophysics