Helicobacter pylori infection and α-synuclein pathology drive parallel neurodegenerative pathways in the substantia nigra
Alejandro Soto-Avellaneda, Alice Prigent, Lindsay K. Meyerdirk, Noah Schautz, John Andrew Pospisilik, Lena Brundin, Michael X. Henderson
This study shows chronic H. pylori infection causes brain inflammation and dopaminergic neuron loss through inflammation, independent of α-synuclein pathology, and eradication reduces these effects.
Journal of Neuroinflammation · Dec 22, 2025Peer-reviewedNeuroscience