Lindsay K. Meyerdirk

This study shows that neuroinflammation occurs early in a mouse model of prodromal Parkinson's disease before neuronal loss, linking Syn pathology to olfactory dysfunction.

This study shows chronic H. pylori infection causes brain inflammation and dopaminergic neuron loss through inflammation, independent of α-synuclein pathology, and eradication reduces these effects.

This study shows that tau filament seeding capacity depends on both core structure and phosphorylation in the fuzzy coat, with phospho-mimetic residues restoring activity in modified tau.

The paper identifies group II p21-activated kinases as regulators of α-synucleinopathy by linking network vulnerability analysis to gene expression and pharmacological interventions.

The paper uses spatial transcriptomics to identify specific cortical neurons vulnerable to Lewy pathology in PD and discovers a conserved molecular dysfunction signature in both mice and humans.

This study identifies up-regulation of human endogenous retrovirus (HERV) transcripts in Parkinson's disease (PD) across multiple tissues and blood, linking TE activation to PD pathogenesis and potential treatment monitoring.

This study investigates how alpha-synuclein aggregation in the basolateral amygdala affects glutamatergic transmission, finding that it selectively disrupts cortico-BLA synapses.

This study shows that T cells reduce phosphorylated α-synuclein pathology in a mouse model of α-synucleinopathy.

The paper tests if inhibiting the mitochondrial pyruvate carrier reduces synucleinopathy in PD models but finds no effect on Syn aggregation or neurodegeneration.

This study shows that injecting α-synuclein fibrils into the olfactory bulb of mice reduces odor detection sensitivity, detected by plethysmography but not buried pellet tests.