John Andrew Pospisilik

This study shows chronic high-fat diet-induced obesity does not increase cancer incidence in Trp53R270H/+ mice, despite significant obesity and long-term adiposity differences.

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

This study shows chronic H. pylori infection causes brain inflammation and dopaminergic neuron loss through inflammation, independent of α-synuclein pathology, and eradication reduces these effects.

This study profiles DNA methylation in COVID-19 patients and finds hypomethylation linked to neurological pathways in severe cases.

The paper analyzes piRNA expression variation across mouse strains and finds genetic differences contribute to strain-specific piRNA production, including from retrovirus insertions and protein-coding genes.

BifurcatoR identifies clinically relevant subgroups by analyzing variance patterns in biological data, revealing hidden structures in AML and obesity.

This study identifies up-regulation of human endogenous retrovirus (HERV) transcripts in Parkinson's disease (PD) across multiple tissues and blood, linking TE activation to PD pathogenesis and potential treatment monitoring.

The paper shows that maternal prenatal stress reduces placental and fetal thyroid hormone availability in female offspring, independent of maternal hormone levels.

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.

The paper finds increased levels of neurotoxic metabolites in mild COVID-19 patients, associated with inflammation and hypertension.

The paper identifies sequence features of retrotransposons that influence epigenetic variability in DNA methylation, particularly in IAPs, by affecting KZFP and ZF-CxxC protein interactions.

An Rcpp implementation brings non-negative matrix factorization to singular-value-decomposition-like runtimes on sparse single-cell matrices, adding a scaling diagonal that keeps regularization penalties consistent across random initializations.

This study shows that paternal dietary sugar affects offspring gene expression through sperm piRNA pathways, linking small RNA regulation to intergenerational epigenetic inheritance.

This study shows that T cells reduce phosphorylated α-synuclein pathology in a mouse model of α-synucleinopathy.

This study identifies elevated toxic bile acids in Parkinson's disease patients and links them to gut microbiome dysbiosis and early biliary changes.

CRUP predicts condition-specific regulatory units by analyzing histone modification ChIP-seq data and linking enhancers to target genes in rheumatoid arthritis.

This study identifies chromatin-state signatures linked to β-cell dysfunction and diabetes by combining epigenome mapping with single-cell transcriptomics in mice and humans.