Reem Al Mubarak

Comprehensive preclinical reevaluation of PaBQU and DBQU regimens identifies lesional liability in hard-to-treat forms of tuberculosis

This study reevaluates PaBQU and DBQU regimens in mouse models, finding they have lesional liability in complex lesions, which may explain their failure in a human trial.

Adaptive immunity shapes baseline physiology of M. tuberculosis in high-dose versus low-dose infection BALB/c mouse drug treatment models

This study compares M. tuberculosis physiology in high-dose and low-dose infection models, showing how adaptive immunity affects bacterial metabolism and drug efficacy.

Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in mice

This study investigates the physiologic recovery of Mycobacterium tuberculosis in mice after antibiotic treatment, finding that recovery is slow, sequential, and incomplete, with longer treatment leading to slower recovery.

Deconvoluting drug interactions based on M. tuberculosis physiologic processes:Transcriptional disaggregation of the BPaL regimen in vivo

The paper uses SEARCH-TB to analyze drug interactions in M. tuberculosis by measuring transcriptional responses to the BPaL regimen in vivo, showing complex effects of drug combinations.

Emergence of antibiotic-specific Mycobacterium tuberculosis phenotypes during prolonged treatment of mice

This study examines how prolonged antibiotic treatment affects M. tuberculosis physiology in mice, finding that sterilizing and non-sterilizing antibiotics induce distinct transcriptional responses.