RNA polymerase loss by nuclear rupture drives LMNA cardiomyopathy
Atsuki En, Melanie E. Gucwa, Erjola Rapushi, Cara L Barnett, Wataru Katano, Nonso Nduka, Tatsuya Shiraki, Alyssa Grogan, Aloke Virmani Finn, K. Nicole Weaver, Kohta Ikegami
This study shows that nuclear rupture in LMNA-DCM leads to transcriptional deficiency and identifies resealing as a protective mechanism that is ultimately insufficient.
bioRxiv · Apr 4, 2026 · PreprintMolecular Biology