Kohta Ikegami

RNA polymerase loss by nuclear rupture drives LMNA cardiomyopathy

This study shows that nuclear rupture in LMNA-DCM leads to transcriptional deficiency and identifies resealing as a protective mechanism that is ultimately insufficient.

Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblasts

The paper co-profiles nascent transcription and mature RNA in cycling human fibroblasts and finds their dynamics are concordant without a transcription-to-maturation lag.

Nutrient starvation activates ECM remodeling gene enhancers associated with inflammatory bowel disease risk in fibroblasts

The paper shows nutrient starvation activates ECM remodeling gene enhancers linked to IBD risk in fibroblasts, suggesting a mechanism for pathological fibroblast activation in IBD.

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

The paper shows that NE ruptures occur before ECM signaling and disease in Lamin-cardiomyopathy mice without activating cGAS-STING.

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment

This paper identifies sequential phases of ETV2-dependent gene expression that drive hematoendothelial fate commitment from mesoderm progenitors.

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

This study identifies a gene regulatory network involving Tbx5, RA, Hedgehog, and Wnt signaling that coordinates cardiopulmonary development.

Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria

Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans

The paper identifies extra-TFIIIC binding sites in C. elegans that cluster near heterochromatin boundaries, suggesting a role in chromatin organization.

Depolymerized lamins link nuclear envelope breakdown to mitotic transcriptional quiescence

This study identifies depolymerized LMNA as a mediator of mitotic transcriptional quiescence by linking nuclear envelope breakdown to transcriptional repression.