Author

Atsuki En

Cincinnati Children's Hospital Medical CenterORCID 0009-0004-9864-0715Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Kohta IkegamiiD· 2 shared Alexis V. StutzmaniD· 1 shared Aloke Virmani FinniD· 1 shared Alyssa GroganiD· 1 shared Briana Thomas· 1 shared Brigitte LaForestiD· 1 shared Cara L BarnettiD· 1 shared Erjola Rapushi· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Kohta IkegamiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RNA polymerase loss by nuclear rupture drives LMNA cardiomyopathy

Atsuki En, Melanie E. Gucwa, Erjola Rapushi, Cara L Barnett, Wataru Katano, Nonso Nduka, Tatsuya Shiraki, Alyssa Grogan, Aloke Virmani Finn, K. Nicole Weaver, Kohta Ikegami

This study shows that nuclear rupture in LMNA-DCM leads to transcriptional deficiency and identifies resealing as a protective mechanism that is ultimately insufficient.

bioRxiv · Apr 4, 2026 · PreprintMolecular Biology

Disturbed proteostasis is the key event that triggers cellular senescence through the regulation of chromatin organization and genome stability

Yuki Takauji, Keisuke Tanabe, Haruna Miyashita, Takuma Katakawa, Saeri Fujii, Atsuki En, Michihiko Fujii

bioRxiv · Mar 3, 2025 · PreprintCell Biology

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis V. Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P. G. Moskowitz, Kohta Ikegami

The paper shows that NE ruptures occur before ECM signaling and disease in Lamin-cardiomyopathy mice without activating cGAS-STING.

Cell Reports · May 29, 2024Peer-reviewedMolecular Biology