Author

Melanie E. Gucwa

Cincinnati Children's Hospital Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Kohta IkegamiiD· 2 shared Aloke Virmani FinniD· 1 shared Alyssa GroganiD· 1 shared Atsuki EniD· 1 shared Cara L BarnettiD· 1 shared Erjola Rapushi· 1 shared K. Nicole WeaveriD· 1 shared Nonso Nduka· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Kohta IkegamiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintApr 4, 2026

RNA polymerase loss by nuclear rupture drives LMNA cardiomyopathy

Atsuki En, Melanie E. Gucwa, Erjola Rapushi…·Kohta Ikegami

This study shows that nuclear rupture in LMNA-DCM leads to transcriptional deficiency and identifies resealing as a protective mechanism that is ultimately insufficient.

1 citation

mousehuman

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GenomicsbioRxivPreprintSep 12, 2025

Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblasts

Melanie E. Gucwa, Kohta Ikegami

The paper co-profiles nascent transcription and mature RNA in cycling human fibroblasts and finds their dynamics are concordant without a transcription-to-maturation lag.

1 citation

humanbulk RNA-seq

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