Doxorubicin-induced Cardiotoxicity is Propagated by Paracrine Signaling through Small Extracellular Vesicles
George Ronan, Lara Ece Celebi, Nicole Kowalczyk, Noor Behnam, Lauren Hawthorne, Jun Yang, Frank Ketchum, Aoïfe Lowery, Michael Joseph Kerin, Pınar Zorlutuna
This study shows DOX-induced cardiotoxicity spreads via paracrine signaling through extracellular vesicles, with plasma EV miRNA profiles indicating risk stratification and potential biomarkers for early detection.
Acta Biomaterialia · Aug 28, 2026Peer-reviewedBioengineering