Frank Ketchum

This study shows DOX-induced cardiotoxicity spreads via paracrine signaling through extracellular vesicles, with plasma EV miRNA profiles indicating risk stratification and potential biomarkers for early detection.

This study shows that adding macrophages to cardiomyocytes improves their metabolic maturity through mitochondrial clearance and mitophagy.

This study uses instant FLIM to show that mechanical compression of stromal cells in breast cancer models alters their metabolism, with distinct effects on fibroblasts and adipocytes, validated by transcriptomics and mitochondrial analysis.

This study develops a 3D bone marrow-on-a-chip model to investigate interactions between CAR-T cells and multiple myeloma cells in different niches and assess therapeutic responses.