Edward M. Callaway

A disinhibitory basal forebrain to cortex projection supports sustained attention

This paper identifies a disinhibitory basal forebrain to cortex projection that regulates sustained attention by modulating cortical gain based on motivational salience.

Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions

The paper shows that corticostriatal projections to D1- and D2-SPNs are asymmetrically overlapping and that pathway-specific subcircuits control distinct behaviors.

Complementary Organization of Driver and Modulator Cortico-Thalamo-Cortical Circuits

The paper maps cortico-thalamo-cortical circuits in mice, revealing complementary rules for driver and modulator connections in higher visual areas.

Parallel pathways carrying direction and orientation selective retinal signals to layer 4 of mouse visual cortex

The paper investigates how direction and orientation selectivity in mouse V1 layer 4 neurons is influenced by retinal inputs through parallel pathways.

High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

This study develops high-resolution methods to identify thin layers in macaque V1 using Neuropixels probes by analyzing electrical signals and spike waveforms.

Quantification of Monosynaptic Rabies Tracing Efficiency

The paper quantifies the efficiency of retrograde monosynaptic rabies virus tracing in mouse primary visual cortex, finding about 40% of first-order presynaptic excitatory inputs are labeled.

Transcriptomic cytoarchitecture reveals principles of human neocortex organization

The paper uses single nucleus RNA-sequencing to analyze human cortical areas, revealing cell type proportions and gene expression patterns that correlate with functional connectivity and areal specialization.

Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections

The paper links single-cell epigenomes and projection patterns of 33,034 mouse neurons to identify transcriptomic and epigenomic properties of projection cell types.

Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex

The paper analyzes gene regulatory programs in the neocortex of rodents and primates using single-cell multiomics, finding rapid evolution of cell type-specific gene expression and TE-driven cCREs.

Cone Opponent Functional Domains in Primary Visual Cortex Combine Signals for Color Appearance Mechanisms

The paper shows that cone-opponent signals in V1 are organized into functional domains that generate color appearance through spatially ordered neural circuits.

A multimodal cell census and atlas of the mammalian primary motor cortex

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

DNA Methylation Atlas of the Mouse Brain at Single-Cell Resolution

The paper constructs a DNA methylation atlas of the mouse brain at single-cell resolution, revealing epigenetic diversity and spatial organization of neuronal subtypes.

Epigenomic Diversity of Cortical Projection Neurons in the Mouse Brain

The paper links epigenomic properties of cortical projection neurons to their anatomical and projection patterns using single-nucleus DNA methylation sequencing in mice.

Distinct 'driving' versus 'modulatory' influences of different visual corticothalamic pathways

The paper shows that layer 5 corticothalamic projections drive visual responses in the pulvinar, while layer 6 provides baseline excitation, with subcortical inputs also contributing.

Monosynaptic projections to excitatory and inhibitory preBotzinger Complex neurons

This study identifies monosynaptic projections to excitatory and inhibitory preBotzinger Complex neurons from brainstem and suprapontine regions using rabies tracing.

Context-Dependent and Dynamic Functional Influence of Corticothalamic Pathways to First- and Higher-order Visual Thalamus

This study investigates how corticothalamic pathways modulate first- and higher-order visual thalamic nuclei in awake mice through optogenetic stimulation and electrophysiology, revealing context-dependent and dynamic effects.

Higher-order thalamic circuits channel parallel streams of visual information in mice

The paper identifies three subregions in the mouse lateral posterior nucleus that form corticothalamic loops biased towards ventral or dorsal visual streams and reveal distinct input sources driving their activity.