IgA antibodies against oxidation-specific epitopes are generated by double negative B cells and are associated with impaired lung function in fibrotic interstitial lung diseases.
Eva Otoupalova, Riley T. Hannan, Pearl Raichura, Noora Batrash, Paul Dell, Mônica Josiane Rodrigues‐Jesus, Eli R. Zunder, Jeffrey M. Wilson, Judith A. Woodfolk, Justin J. Taylor, Shwu‐Fan Ma, Andrew Julio Barros, Yun Michael Shim, Imre Noth, Catherine A. Bonham, , Jeffrey M. Sturek
This study identifies elevated anti-oxidation-specific epitope (OSE) IgA antibodies in fibrotic interstitial lung diseases (fILD) and links them to impaired lung function and a specific B cell subset.
bioRxiv · Dec 2, 2025 · PreprintImmunology