Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cells
Volker Boehm, Damaris Wallmeroth, Paul O. Wulf, Oliver Popp, Luiz Gustavo Teixeira Alves, Lucie Reinecke, Maximilian Riedel, Emanuel Wyler, Marek Franitza, Kerstin Becker, Karina Polkovnychenko, Simone Del Giudice, Nouhad Benlasfer, Philipp Mertins, Markus Landthaler, Niels H. Gehring
This study rapidly depletes UPF1 in human cells to investigate NMD-regulated transcriptome dynamics, identifying core transcripts and biological processes affected.
Molecular Cell · Sep 1, 2025Peer-reviewedMolecular Biology