Luca F. R. Gebert

This study identifies organyl 5'-phosphate mimics that enhance AGO2 binding and metabolic stability by interacting with a hydrophobic pocket in the MID domain.

This study reveals the structural mechanism of siRNA-mediated gene silencing by hAgo2, showing how specific residues and duplex distortions enable catalytic activity.

This study investigates bacterial ribosome assembly using circularly permuted rRNAs, revealing conserved assembly routes and domain association order.