Author

Theodore Carrigan-Broda

University of Massachusetts Chan Medical SchoolORCID 0000-0002-0115-412XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 1 shared Atish A. WaghiD· 1 shared Dimas EcheverriaiD· 1 shared Eric LuuiD· 1 shared Ian J. MacRaeiD· 1 shared Jillian CaiazziiD· 1 shared Jonathan K. WattsiD· 1 shared Ken YamadaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Anastasia KhvorovaORCID

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1 paper

Recent·Most cited

Organyl 5'-Phosphates in siRNA Guide Strands: Structure-Function Relationships Governing Anchoring in Argonaute 2 and Metabolic Stability

Theodore Carrigan-Broda, Luca F. R. Gebert, Samuel R. Hildebrand, Nozomi Yamada, Eric Luu, Jillian Caiazzi, Nicholas McHugh, Dimas Echeverria, Atish A. Wagh, Jonathan K. Watts, Anastasia Khvorova, Ian J. MacRae, Ken Yamada

This study identifies organyl 5'-phosphate mimics that enhance AGO2 binding and metabolic stability by interacting with a hydrophobic pocket in the MID domain.

bioRxiv · Feb 14, 2026 · PreprintMolecular Biology