Author

Alexandra Weiss

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Nicholas Wightman· 2 shared Robert H. BrowniD· 2 shared Alexander JaworskiiD· 1 shared Alper KüçükuraliD· 1 shared Anastasia KhvorovaiD· 1 shared Ashley L. HarkinsiD· 1 shared Ashley SummersiD· 1 shared Brianna Bramato· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Nicholas Wightman

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2 papers

Recent·Most cited

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

Alexandra Weiss, James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal M. Ferguson, Elif O. Dogan, Nicholas Wightman, Kit Mocarski, Dimas Echeverria, Ashley L. Harkins, Ashley Summers, Brianna Bramato, Nicholas McHugh, Raymond C. Furgal, Nozomi Yamada, , Anastasia Khvorova

The paper shows that silencing SOD1 with optimized di-siRNA extends survival and prevents disease progression in ALS mice.

Molecular Therapy · May 9, 2025Peer-reviewedNeuroscience

Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in Sod1 mutant mouse model of ALS.

Janice A. Dominov, Laura A. Madigan, Joshua P. Whitt, Katerina Rademacher, Kristin M. Webster, Hesheng Zhang, Haruhiko Banno, Siqi Tang, Yifan Zhang, Nicholas Wightman, Emma M. Shychuck, John Page, Alexandra Weiss, Karen L. Kelly, Alper Küçükural, , Robert H. Brown

This study shows that Sod1G85R knock-in mice exhibit up-regulated cholesterol synthesis pathways and limited neurodegeneration, contrasting with severe TgSOD1G93A mice, suggesting lipid pathway dysregulation in ALS.

bioRxiv · May 5, 2023 · PreprintNeuroscience