PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation
Hannah Brunsdon, Nuoya Wang, Micha Sam Brickman Raredon, Ralitsa Radostinova Madsen, Robert K. Semple, E. Elizabeth Patton
The paper develops zebrafish models of PROS to show that PIK3CA mutations cause non-cell-autonomous overgrowth through pan-lineage gene expression and communication changes.
bioRxiv · Feb 2, 2026 · PreprintDevelopmental Biology