Author

O. D. Schärer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1 Organism:yeast· 1

Frequent Co-Authors

A. D'Souza· 1 shared A. M. Blee· 1 shared C. R. Troll· 1 shared H.-S. Kim· 1 shared J. Park· 1 shared K. S. Gallagher· 1 shared M. Kim· 1 shared P. D. Neufer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. D'Souza

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

XPA tumor variants lead to defects in NER that sensitize cells to cisplatin

A. M. Blee, K. S. Gallagher, H.-S. Kim, M. Kim, C. R. Troll, A. D'Souza, J. Park, P. D. Neufer, O. D. Schärer, W. J. Chazin

This study identifies XPA tumor variants that impair NER, increasing cisplatin sensitivity, and provides mechanistic insights for variant effect prediction.

bioRxiv · Jun 29, 2023Cancer Biology

Bypass of DNA Interstrand crosslinks by a Rev1-DNA polymerase ζ complex

R. B. Buch, Y. K. Cheun, U. Roy, O. D. Schärer, P. M. Burgers

This study shows that the Rev1-Pol ζ complex is more efficient than Pol ζ alone or Pol η in bypassing ICL damage, with Rev1's structural role being critical for TLS efficiency.

bioRxiv · May 9, 2020 · PreprintBiochemistry