PFKFB3 DEPLETION ACTIVATES β-CELL REPLICATION BY CELL COMPETITIVE CULLING OF COMPROMISED β-CELLS UNDER STRESS
J. Min, F. Ma, M. Pellegrini, O. Greeff, S. Moncada, S. Tudzarova
This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.
bioRxiv · Apr 7, 2021 · PreprintCell Biology