Decorin, a novel negative modulator of E-cadherin in inflammatory breast cancer
X. Hu, E. Schlee Villodre, R. A. Larson, O. M. Rahal, X. Wang, Y. Gong, J. Song, S. Krishnamurthy, N. T. Ueno, D. Tripathy, W. A. Woodward, B. G. Debeb
This study identifies decorin as a negative regulator of E-cadherin in inflammatory breast cancer, showing it reduces migration, invasion, and metastasis by destabilizing E-cadherin and inhibiting EGFR/ERK signaling.
bioRxiv · Jul 7, 2020Cancer Biology