Temporal control of the integrated stress response by a stochastic molecular switch
P. Klein, S. M. Kallenberger, H. Roth, K. Roth, T. B. N. Ly-Hartig, V. Magg, J. Ales, S. Rastgou Talemi, Y. Qiang, S. Wolf, O. Oleksiuk, R. Kurilov, B. Di Ventura, R. Bartenschlager, R. Eils, , A. Ruggieri
The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.
bioRxiv · Jan 1, 2022Cell Biology