A. Ruggieri

Turnover of PPP1R15A mRNA encoding GADD34 controls the molecular memory of the cellular integrated stress response

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

The paper shows that the mitochondrial unfolded protein response (UPRmt) interacts with stress granules (SGs) to regulate cellular stress responses and mitochondrial homeostasis.

Temporal control of the integrated stress response by a stochastic molecular switch

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

A versatile reporter system to monitor virus infected cells and its application to dengue virus and SARS-CoV-2

This paper introduces a versatile reporter system that detects virus-infected cells by using protease activity and applies it to dengue virus and SARS-CoV-2.

Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency

This paper develops a method to control cytokine signaling using light-activated polymers that induce latency and release cytokines on demand.

CDK1 couples proliferation with protein synthesis

This study identifies CDK1 as a regulator of translation that couples cell proliferation with protein synthesis by modulating 5TOP mRNA translation through LARP1.

Norovirus infection results in assembly of virus-specific G3BP1 granules and evasion of eIF2α signaling.

This study shows that norovirus infection leads to the formation of virus-specific granules and disrupts eIF2α signaling to evade host stress responses.