Y. Qiang

Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics

This study uses computational models to show that deformable interendothelial slits in the spleen better predict RBC filtration compared to rigid models, improving understanding of splenic hemodynamics and filtration mechanisms.

Early evolution of the ecdysozoan body plan

The paper describes a new Cambrian ecdysozoan species, Beretella spinosa, and suggests that ancestral ecdysozoans may have been non-vermiform.

Long-Term In Vivo Molecular Monitoring Using Aptamer-Graphene Microtransistors

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

A combined computational and experimental investigation of the filtration function of splenic macrophages in sickle cell disease

This study combines computational modeling and experiments to show that hypoxia and RBC aggregation enhance macrophage retention of sickle RBCs, contributing to splenic congestion in SCD.

Temporal control of the integrated stress response by a stochastic molecular switch

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

Electrical impedance detection of sickle cell vaso-occlusion in microfluidic capillary structures

This study develops an electrical impedance sensing method to detect sickle cell vaso-occlusion in microfluidic capillaries, showing distinct impedance changes during deoxygenation and reoxygenation.

A Portable Impedance Microflow Cytometer for Measuring Cellular Response to Hypoxia

This paper develops a portable impedance microflow cytometer to measure cellular response to hypoxia, showing changes in electrical properties of sickle cell RBCs under hypoxia.