Author

O. Otto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:flow cytometry· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Jacobi· 3 shared J. Guck· 3 shared M. Herbig· 3 shared A. Greinacher· 2 shared C. Herold· 2 shared L. Sachs· 2 shared M. Bender· 2 shared M. Bornhauser· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

A. Jacobi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PIEZO1-mediated mechanosensing governs NK cell killing efficiency and infiltration in three-dimensional matrices

A. K. Yanamandra, J. Zhang, G. Montalvo, X. Zhou, D. Biedenweg, R. Zhao, S. Sharma, M. Hoth, F. Lautenschlaeger, O. Otto, A. del Campo, B. Qu

This study shows that PIEZO1-mediated mechanosensing affects NK cell killing efficiency and infiltration in 3D matrices by responding to tumor cell stiffness.

bioRxiv · Mar 27, 2023Immunology

Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping.

L. Sachs, J. Wesche, L. Lenkeit, A. Greinacher, M. Bender, O. Otto, R. Palankar

This study shows ex vivo anticoagulants affect platelet biomechanics and demonstrates their impact on mechanophenotyping in a MYH9-related disorder.

Communications Biology · Jan 21, 2022Peer-reviewedCell Biology

Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease

J. Baumann, L. Sachs, O. Otto, I. Schoen, P. Nestler, C. Zaninetti, M. Kenny, R. Kranz, H. von Eysmondt, J. Rodriguez, T. Schaeffer, Z. Nagy, A. Greinacher, R. Palankar, M. Bender

This study shows that reduced platelet forces in Myh9 mutant mice cause impaired hemostasis, which can be improved by tranexamic acid.

bioRxiv · Nov 10, 2021Cell Biology

Spheroid culture of mesenchymal stromal cells results in morpho-rheological properties appropriate for improved microcirculation

S. Tietze, M. Krater, A. Jacobi, A. Taubenberger, M. Herbig, R. Wehner, M. Schmitz, O. Otto, C. List, B. Kaya, M. Wobus, M. Bornhauser, J. Guck

This study shows that culturing mesenchymal stromal cells in 3D spheroids improves their morpho-rheological properties, enhancing their ability to circulate through microvascular networks.

bioRxiv · Oct 11, 2018Biophysics

Real-time fluorescence and deformability cytometry - flow cytometry goes mechanics

P. Rosendahl, K. Plak, A. Jacobi, M. Kraeter, N. Toepfner, O. Otto, C. Herold, M. Winzi, M. Herbig, Y. Ge, S. Girardo, K. Wagner, B. Baum, J. Guck

This paper introduces RT-FDC, combining real-time fluorescence imaging with deformability cytometry to enable label-free, high-throughput mechanical and molecular cell analysis.

bioRxiv · Sep 11, 2017Biophysics

Detection Of Human Disease Conditions By Single-Cell Morpho-Rheological Phenotyping Of Whole Blood

N. Toepfner, C. Herold, O. Otto, P. Rosendahl, A. Jacobi, M. Krater, J. Stachele, L. Menschner, M. Herbig, L. Ciuffreda, L. Ranford-Cartwright, M. Grzybek, U. Coskun, E. Reithuber, G. Garriss, , J. Guck

This paper introduces a method to detect human disease conditions by analyzing whole blood using morpho-rheological phenotyping without labeling or separation.

bioRxiv · Jun 1, 2017Biophysics