An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency
T. Kotaki, T. Kurosu, A. Grinyo, E. Davidson, S. Churrotin, T. Okabayashi, O. Puiprom, K. C. Mulyatno, T. H. Sucipto, B. Doranz, K.-i. Ono, S. Soegijanto, M. Kameoka
This study identifies an affinity-matured human monoclonal antibody, 3G9, targeting the fusion loop epitope of dengue virus that shows strong neutralization and reduced antibody-dependent enhancement in vivo.
bioRxiv · Oct 3, 2020Microbiology