Author

T. Kotaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Organism:virus· 1

Frequent Co-Authors

M. Kameoka· 5 shared A. Grinyo· 1 shared A. Kawayoshi· 1 shared A. Yamanaka· 1 shared B. Doranz· 1 shared C. Utsubo· 1 shared E. Davidson· 1 shared E. Konishi· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersMicrobiology

M. Kameoka

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Construction of Fosmid-based SARS-CoV-2 replicons for antiviral drug screening and replication analyses in biosafety level 2 facilities

S. Takazawa, T. Kotaki, S. Nakamura, C. Utsubo, M. Kameoka

This paper constructs SARS-CoV-2 replicons for antiviral drug screening in BSL-2 facilities and validates their replication and functionality.

bioRxiv · Feb 15, 2023Microbiology

Inactivation of SARS-CoV-2 and influenza A virus by spraying hypochlorous acid solution and hydrogen peroxide solution in the form of Dry Fog

M. Urushidani, A. Kawayoshi, T. Kotaki, K. Saeki, Y. Mori, M. Kameoka

This study evaluates the effectiveness of dry fog disinfectants in inactivating SARS-CoV-2 and influenza A virus on surfaces.

bioRxiv · Dec 13, 2021 · PreprintMicrobiology

An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency

T. Kotaki, T. Kurosu, A. Grinyo, E. Davidson, S. Churrotin, T. Okabayashi, O. Puiprom, K. C. Mulyatno, T. H. Sucipto, B. Doranz, K.-i. Ono, S. Soegijanto, M. Kameoka

This study identifies an affinity-matured human monoclonal antibody, 3G9, targeting the fusion loop epitope of dengue virus that shows strong neutralization and reduced antibody-dependent enhancement in vivo.

bioRxiv · Oct 3, 2020Microbiology

A potent neutralizing mouse monoclonal antibody specific to dengue virus type 1 Mochizuki strain recognized a novel epitope around the N-67 glycan on the E protein: a possible explanation of dengue virus evolution regarding the acquisition of N-67 glycan

T. Kotaki, A. Yamanaka, E. Konishi, M. Kameoka

This study identifies a novel epitope on dengue virus type 1 E protein recognized by a neutralizing antibody, showing that viral evolution may have selected for N-67 glycan to escape immune pressure.

bioRxiv · Oct 3, 2020Microbiology

A PCR amplicon-based SARS-CoV-2 replicon for antiviral screening

T. Kotaki, X. Xie, P.-Y. Shi, M. Kameoka

This paper develops a PCR-based SARS-CoV-2 replicon system for antiviral screening, showing robust replication and inhibition by remdesivir.

bioRxiv · Aug 28, 2020Microbiology