Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
N. He, L. Depta, C. Rossetti, M. Cigler, M. Michon, O. R. Dan, J. G. F. Hoock, J. Barbier, D. Gillet, A. Forrester, G. E. Winter, L. Laraia
This study identifies oxybipins, selective OSBP inhibitors, which block retrograde trafficking and reduce Shiga toxin toxicity by inducing Golgi degradation.
bioRxiv · Apr 1, 2023 · PreprintCell Biology