Author

J. G. F. Hoock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Rossetti· 2 shared L. Depta· 2 shared L. Laraia· 2 shared A. Forrester· 1 shared D. Gillet· 1 shared G. E. Winter· 1 shared J. Barbier· 1 shared J. C. Christianson· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

C. Rossetti

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2 papers

Recent·Most cited

Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

N. He, L. Depta, C. Rossetti, M. Cigler, M. Michon, O. R. Dan, J. G. F. Hoock, J. Barbier, D. Gillet, A. Forrester, G. E. Winter, L. Laraia

This study identifies oxybipins, selective OSBP inhibitors, which block retrograde trafficking and reduce Shiga toxin toxicity by inducing Golgi degradation.

bioRxiv · Apr 1, 2023 · PreprintCell Biology

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

J. G. F. Hoock, C. Rossetti, M. Bilgin, L. Depta, K. Enemark-Rasmussen, J. C. Christianson, L. Laraia

This study identifies small molecules that either degrade or stabilize squalene synthase, showing that degradation is possible despite challenges and providing a foundation for future probe development.

Chemical Science · Jan 1, 2023Peer-reviewedCell Biology