Author

L. Laraia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

C. Rossetti· 3 shared L. Depta· 3 shared G. E. Winter· 2 shared J. G. F. Hoock· 2 shared M. Cigler· 2 shared A. Cooke· 1 shared A. Forrester· 1 shared A. Recino· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

C. Rossetti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

N. He, L. Depta, C. Rossetti, M. Cigler, M. Michon, O. R. Dan, J. G. F. Hoock, J. Barbier, D. Gillet, A. Forrester, G. E. Winter, L. Laraia

This study identifies oxybipins, selective OSBP inhibitors, which block retrograde trafficking and reduce Shiga toxin toxicity by inducing Golgi degradation.

bioRxiv · Apr 1, 2023 · PreprintCell Biology

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

M. Cigler, H. Imrichova, F. Frommelt, L. Depta, A. Rukavina, C. Kagiou, J. T. Hannich, C. Mayor-Ruiz, G. Superti-Furga, S. Sievers, L. Laraia, H. Waldmann, G. E. Winter

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

bioRxiv · Mar 15, 2023 · PreprintPharmacology & Toxicology

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

J. G. F. Hoock, C. Rossetti, M. Bilgin, L. Depta, K. Enemark-Rasmussen, J. C. Christianson, L. Laraia

This study identifies small molecules that either degrade or stabilize squalene synthase, showing that degradation is possible despite challenges and providing a foundation for future probe development.

Chemical Science · Jan 1, 2023Peer-reviewedCell Biology

Thermal proteome profiling reveals distinct target selectivity for differentially oxidized oxysterols

C. Rossetti, L. Laraia

The paper uses thermal proteome profiling to identify distinct target selectivity of oxidized oxysterols, revealing unique protein interactions and shared pathways in lipid metabolism and vesicular transport.

bioRxiv · Jan 5, 2021Biochemistry

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

A. Recino, K. Barkan, A. Schmidt-Christensen, J. Nilsson, N. Holmes, D. Howie, D. Holmberg, P. Larsson, M. Flodstrom-Tullberg, L. Laraia, D. R. Spring, J. Hecksher-Sorensen, A. Cooke, G. Ladds, M. Wallberg

This study shows that GLP-1R is downregulated in beta cells of NOD mice and T1D patients, likely due to accelerated degradation, and suggests a role in autoimmune inflammation.

bioRxiv · Nov 17, 2019 · PreprintPhysiology