G. E. Winter

Degradome analysis to identify direct protein substrates of small-molecule degraders

The paper introduces a method to identify direct protein substrates of small-molecule degraders using degradome analysis and mass spectrometry.

Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

This study identifies oxybipins, selective OSBP inhibitors, which block retrograde trafficking and reduce Shiga toxin toxicity by inducing Golgi degradation.

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

Targeted protein degradation via intramolecular bivalent glues

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.