Author

O. W. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

I. E. Wertz· 2 shared A. Osa· 1 shared B. E. A. Poblano· 1 shared D. K. Nomura· 1 shared D. Nomura· 1 shared F. A. Gowans· 1 shared J. Hatcher· 1 shared N. Forte· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

I. E. Wertz

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Author profile →

2 papers

Recent·Most cited

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

F. A. Gowans, N. Forte, J. Hatcher, O. W. Huang, Y. Wang, B. E. A. Poblano, I. E. Wertz, D. K. Nomura

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

bioRxiv · Oct 31, 2023Biochemistry

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

S. H. Hong, A. Osa, O. W. Huang, I. E. Wertz, D. Nomura

This study identifies a covalent recruiter against SKP1 for PROTAC-based protein degradation, demonstrating its efficacy in degrading BRD4 and androgen receptor via the SCF complex.

bioRxiv · Oct 20, 2023Biochemistry