Author

N. Forte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

D. K. Nomura· 2 shared B. E. A. Poblano· 1 shared D. Dovala· 1 shared F. A. Gowans· 1 shared I. E. Wertz· 1 shared J. A. Tallarico· 1 shared J. Hatcher· 1 shared J. M. McKenna· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

D. K. Nomura

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

F. A. Gowans, N. Forte, J. Hatcher, O. W. Huang, Y. Wang, B. E. A. Poblano, I. E. Wertz, D. K. Nomura

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

bioRxiv · Oct 31, 2023Biochemistry

Targeted Protein Degradation through E2 Recruitment

N. Forte, D. Dovala, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This study identifies a covalent recruiter for the E2 ubiquitin conjugating enzyme UBE2D, enabling targeted protein degradation via PROTACs.

bioRxiv · Dec 19, 2022 · PreprintBiochemistry