Author

I. E. Wertz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

O. W. Huang· 2 shared X. Ye· 2 shared A. Ashworth· 1 shared A. Dey· 1 shared A. Osa· 1 shared B. E. A. Poblano· 1 shared C. L. Gilchrist· 1 shared C. L. Noland· 1 shared

Activity by Year

2023-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

O. W. Huang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

F. A. Gowans, N. Forte, J. Hatcher, O. W. Huang, Y. Wang, B. E. A. Poblano, I. E. Wertz, D. K. Nomura

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

bioRxiv · Oct 31, 2023Biochemistry

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

S. H. Hong, A. Osa, O. W. Huang, I. E. Wertz, D. Nomura

This study identifies a covalent recruiter against SKP1 for PROTAC-based protein degradation, demonstrating its efficacy in degrading BRD4 and androgen receptor via the SCF complex.

bioRxiv · Oct 20, 2023Biochemistry

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

T. H. Pham, K. B. Pahuja, T. J. Hagenbeek, J. Zbieg, C. L. Noland, V. C. Pham, X. Yao, C. M. Rose, K. C. Browder, H.-J. Lee, M. Yu, M. Liang-Chu, S. E. Martin, E. Verschueren, J. Li, , A. Dey

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

bioRxiv · Oct 3, 2023 · PreprintCancer Biology

Constitutive protein degradation induces acute cell death via proteolysis products

S.-H. Chen, S. Prakash, E. Helgason, C. L. Gilchrist, L. R. Kenner, R. Srinivasan, T. Sterne-Weiler, M. Hafner, R. Piskol, E. C. Dueber, H. Hamidi, N. Endres, X. Ye, W. J. Fairbrother, I. E. Wertz

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

bioRxiv · Feb 6, 2023 · PreprintCell Biology