Author

Olivier Brison

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Chun-Long CheniD· 2 shared Michelle DebatisseiD· 2 shared Sami El-HilaliiD· 2 shared Stéphane KoundrioukoffiD· 2 shared Anne-Marie LachagèsiD· 1 shared Antoine ToffanoiD· 1 shared Bernard DutrillauxiD· 1 shared Claude ThermesiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetics

Chun-Long ChenORCID

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2 papers

Recent·Most cited

The balance between ATR and DDK activities controls TopBP1-mediated locking of dormant origins at the pre-IC stage

Stéphane Koundrioukoff, Su-Jung Kim, Nathan Alary, Antoine Toffano, Rodrigo Meléndez García, Xia Wu, Yaqun Liu, Stefano Gnan, Sami El-Hilali, Olivier Brison, Filippo Rosselli, Chun-Long Chen, Michelle Debatisse

The paper shows that ATR and DDK control TopBP1-mediated locking of dormant origins at the pre-IC stage, with compensation involving both passive and active processes.

bioRxiv · Nov 29, 2023 · PreprintGenetics

TRANSCRIPTION-MEDIATED ORGANIZATION OF THE REPLICATION INITIATION PROGRAM ACROSS LARGE GENES SETS UP COMMON FRAGILE SITES GENOME-WIDE

Olivier Brison, Sami El-Hilali, Dana Azar, Stéphane Koundrioukoff, Mélanie Schmidt, Viola Nähse, Yan Jaszczyszyn, Anne-Marie Lachagès, Bernard Dutrillaux, Claude Thermes, Michelle Debatisse, Chun-Long Chen

The paper shows that transcription suppresses replication initiation in large genes, leading to delayed replication and instability at common fragile sites.

Nature Communications · Dec 13, 2019Peer-reviewedGenomics