Author

Mélanie Schmidt

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Michelle DebatisseiD· 2 shared Viola NähseiD· 2 shared Anne-Marie LachagèsiD· 1 shared Benoît Le TalleciD· 1 shared Bernard DutrillauxiD· 1 shared Caroline BrossasiD· 1 shared Chun-Long CheniD· 1 shared Claude ThermesiD· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenomics

Michelle DebatisseORCID

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2 papers

Recent·Most cited

TRANSCRIPTION-MEDIATED ORGANIZATION OF THE REPLICATION INITIATION PROGRAM ACROSS LARGE GENES SETS UP COMMON FRAGILE SITES GENOME-WIDE

Olivier Brison, Sami El-Hilali, Dana Azar, Stéphane Koundrioukoff, Mélanie Schmidt, Viola Nähse, Yan Jaszczyszyn, Anne-Marie Lachagès, Bernard Dutrillaux, Claude Thermes, Michelle Debatisse, Chun-Long Chen

The paper shows that transcription suppresses replication initiation in large genes, leading to delayed replication and instability at common fragile sites.

Nature Communications · Dec 13, 2019Peer-reviewedGenomics

Transcription-dependent regulation of replication dynamics modulates genome stability

Marion Blin, Benoît Le Tallec, Viola Nähse, Mélanie Schmidt, Caroline Brossas, Gaël A. Millot, Marie‐Noëlle Prioleau, Michelle Debatisse

The paper investigates how transcription affects replication dynamics and genome stability in large genes, finding that moderate transcription increases instability while high transcription reduces it.

Nature Structural & Molecular Biology · Dec 20, 2018Peer-reviewedMolecular Biology