Yan Jaszczyszyn

Bovine in vitro blastocysts with distinct morphokinetic patterns show transcriptomic differences at genome activation

The paper uses morphokinetic analysis to classify bovine embryos into four blastocyst categories and identifies transcriptomic differences associated with genome activation.

Supporting-like cells constitute an alternative steroidogenic lineage conserved in amniotes

The paper identifies supporting-like cells as an alternative steroidogenic lineage in mammals, conserved across amniotes, and shows their role in embryonic development and evolution.

High-resolution HIV-1 m6A epitranscriptome reveals isoform-dependent methylation clusters and unique 2-LTR transcript modifications

The paper identifies 18 m6A sites in HIV-1 using Nanopore sequencing and reveals isoform-dependent methylation clusters and unique 2-LTR transcript modifications.

A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors

The paper identifies a bifunctional snoRNA, snR107, that guides rRNA modification and scaffolds gametogenesis effectors in fission yeast.

Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells

This study examines how FSH affects mRNA distribution on ribosomes in Sertoli cells, revealing that basal polysomal enrichment influences FSH-induced mRNA recruitment and protein function shifts.

Dual RNA-seq study of the dynamics of coding and non-coding RNAs expression during Clostridioides difficile infection in a mouse model

This paper uses dual RNA-seq to study coding and non-coding RNA expression dynamics in C. difficile infection in mice, identifying new ncRNA genes and host miRNAs associated with infection.

Single cell RNA-sequencing identifies the gene expression profile of the asexual and sexual invasive merozoites of the human malaria parasite

This study uses scRNA-seq to identify gene expression profiles of asexual and sexual merozoites in Plasmodium falciparum, revealing key genes involved in invasion and sexual commitment.

The Drosophila Fab-7 boundary element modulates Abd-B gene activity in the genital disc by guiding an inversion of collinear chromatin organization and alternative promoter use

The paper investigates how the Fab-7 boundary element influences Abd-B gene activity in Drosophila genital discs by altering chromatin organization and promoting alternative promoter use.

Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics

The paper determines the developmental timing of DNA elimination in Paramecium tetraurelia and links it to the evolutionary dynamics of germline transposons.

Major transcriptomic, epigenetic and metabolic changes underly the pluripotency continuum in rabbit preimplantation embryos

This study maps the transcriptomic, epigenetic, and metabolic changes in rabbit preimplantation embryos, identifying novel markers of naive pluripotency and similarities to human and primate embryos.

Nulliparity affects the expression of a limited number of genes and pathways in Day 8 equine embryos

This study examines how maternal parity affects gene expression in Day 8 equine embryos, finding limited gene changes but significant pathway alterations in trophoblast and inner-cell-mass cells.

Maternal parity affects Day 8 embryo gene expression in old mares

The study examines how maternal parity affects Day 8 embryo gene expression in old mares, finding altered gene expression related to nutrient exchange and environmental response.

Paramecium Polycomb Repressive Complex 2 physically interacts with the small RNA binding PIWI protein to repress transposable elements

The paper identifies PRC2 cofactors that mediate small RNA recruitment to repress transposable elements in Paramecium.

TRANSCRIPTION-MEDIATED ORGANIZATION OF THE REPLICATION INITIATION PROGRAM ACROSS LARGE GENES SETS UP COMMON FRAGILE SITES GENOME-WIDE

The paper shows that transcription suppresses replication initiation in large genes, leading to delayed replication and instability at common fragile sites.