Sex-linked Lung Estrobolome May Contribute to Pulmonary Hypertension Penetrance of Bmpr2 R899X Mutation via an ET-1high Endoregulatory Macrophage Phenotype
Omar Loya, Elizabeth S. Villarreal, Alan Brito Carneiro, Stuti Agarwal, Dustin R. Fraidenburg, Jun Sun, Vinicio de Jesús Pérez, Tim Lahm, Suellen D. Oliveira
This study identifies a microbiome-estrogen-immune axis that contributes to sex-linked pulmonary hypertension in Bmpr2 R899X mutation carriers.
bioRxiv · Jun 10, 2026 · PreprintImmunology