Vinicio de Jesús Pérez

This paper describes a method to isolate and characterize primary rat pulmonary pericytes, showing they express pericyte markers and associate with endothelial cells in co-culture.

This study identifies a microbiome-estrogen-immune axis that contributes to sex-linked pulmonary hypertension in Bmpr2 R899X mutation carriers.

The paper uses Perturb-seq in mice to identify genes that promote collateral artery formation by comparing gene expression between guinea pigs and mice.

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

This study uses patient-derived colon organoids to identify lipid-related metabolic dysfunction in pediatric ulcerative colitis and shows that PPAR-α inhibition can alleviate metabolic and inflammatory features.

This study investigates adaptive right ventricular development in congenital heart disease-associated pulmonary arterial hypertension, finding preserved microvascular density and increased cardiomyocyte hyperplasia support RV function.

The paper identifies FABP4/5 as key regulators of endothelial glycolysis and arterial programming in pulmonary hypertension using single-cell and spatial transcriptomics.

This study shows that loss of endothelial c-IAP2 worsens Sch-PH by amplifying P2X7R-driven inflammation and microvascular apoptosis.

The paper identifies disease-associated states in PASMC and PAAF from IPAH patients and identifies potential modulators of PASMC phenotypic transition.